منابع مشابه
Fractalkine in Vascular Biology
Fractalkine (now also called CX3CL1) is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferonand tumor necrosis factor. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lym...
متن کاملFractalkine Depresses Cardiomyocyte Contractility
BACKGROUND Our laboratory reported that male mice with cardiomyocyte-selective knockout of the prostaglandin E2 EP4 receptor sub-type (EP4 KO) exhibit reduced cardiac function. Gene array on left ventricles (LV) showed increased fractalkine, a chemokine implicated in heart failure. We therefore hypothesized that fractalkine is regulated by PGE2 and contributes to depressed contractility via alt...
متن کاملFractalkine: a novel cardiac chemokine?
The endothelium plays a central role in maintaining cardiovascular integrity, function, and the response to injury. A multitude of bioactive molecules is known to be expressed in and secreted from the endothelium under both physiological and pathophysiological circumstances. Xuan et al. uncover a unique role for fractalkine (FKN), a novel membrane-bound chemokine that is mainly expressed in end...
متن کاملFractalkine and in‰ammatory diseases
The migration of leukocytes into in‰amed peripheral tissues and lymphoid organs involves a cascade of molecular events ˆnely regulated by cell adhesion molecules and chemokines. Fractalkine/CX3CL1 is a membrane-bound chemokine that functions not only as a chemoattractant but also as an adhesion molecule, and is expressed on endothelial cells activated by proin‰ammatory cytokines. The fractalkin...
متن کاملDeregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients.
Fractalkine is the only member of the CX3C chemokine family. Polymorphism of the fractalkine receptor gene may influence the prognosis of human immunodeficiency virus (HIV) infection, but the nature of the cells expressing fractalkine or its receptor in HIV-infected patients remains unknown. We show that, in contrast to HIV-uninfected individuals, a large number of cells expressed fractalkine i...
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ژورنال
عنوان ژورنال: Ensho Saisei
سال: 2001
ISSN: 1346-8022,1880-5795
DOI: 10.2492/jsir.21.49